Targeted MRI for Breast Cancer using Iron Oxide Nanoparticles

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چکیده

Magnetic Resonance Imaging (MRI) utilizes a powerful magnetic field to align the nuclear magnetization of hydrogen atoms in water in the body without the use of ionizing radiation. Iron oxide (IO) nanoparticles are the only FDA approved nanoparticles used as a MRI contrast agent. Paramagnetic IO nanoparticles can induce remarkably strong magnetic resonance imaging contrast and have a large surface area and versatile surface chemistry for the introduction of biomolecules. Here we present uPA receptor-targeted ATF-IO nanoparticles as molecularly targeted, dual modality imaging agents for in vivo imaging of breast cancer.

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تاریخ انتشار 2012